While rocketry is older than Newton, even in 1920, it was widely believed that rockets would not work in space (and therefore couldn't get us to the moon).
It's funny to me to imagine that the whole time humans were doing basically anything on this planet, nuclear fission was also already happening in a few places around the world. I wonder how much science would've been jump-started if we'd found any of the natural nuclear reactors prior to having figured fission out already.