In the end it is easier to schedule a weekly reboot window if packages have been updated. You aren't running a single server if you are interested in 99.99999990% of uptime anyway.
Imho a regular reboot is good practice: you are more likely to remember what you did a week earlier if an app/service fail to restart after you tweaked a config file than if it happens months later.
There is no reason to be afraid of reboot when they happen on a regular basis.