> Let's say you let a province (or US state) secede over political/cultural issues. What happens to all of the people who don't want to go along for the ride?

Well, thats politics? The people proposing this are supposed to be considering that. And the people in that position are supposed to be considering that.

Every day there are votes with outcomes people dont want to go along with the ride for. But they do, or they resist, or otherwise.

>>What happens to all of the people who don't want to go along for the ride?

All of Scotland voted against leaving the EU. Every single county has voted no. And yet it still got dragged out.

So I guess the answer is - people get told to shut up and deal with it.