And fuel burn is the least of the concerns when it comes to weight - a far bigger issue is how it affects balance and engine lift. But on a plane the size of a jet airliner, this too is almost never a real concern when it comes to passenger weight - a standard weight is just assumed for each passenger and their carryon. (It's a concern for cargo weight, but that's why cargo is always weighed and balanced properly.)
Maybe if the airline notices that all the passengers are sitting on the left (for some strange reason) or something like that, they would reseat people.
https://aviation.stackexchange.com/questions/16307/how-does-...