Quercitin + Bromelain has also helped my nasal polyps. The biggest improvement has been my ability to breath at night through my nose which has really improved my sleep.

Copilot recommended these supplements. Due to a lack of studies relating directly to the effect of these supplements on nasal polyps, it inferred they might help based on the known action of the supplements and the theorised cause of polyps, so it could all be nonsense. That said, both those supplements are considered safe at the doses I take and it appears to help, so even if it is a placebo effect I'm happy.

Not op but my wife has MCAS. The things that have helped the most are: Oral Cromolyn (helped sooo much with gi issues), and more recently she's started Ketotifen which is a systemic mast cell stabilizer that's seemed promising but is fairly new. She also tried Montelukast which was well tolerated but didn't make a ton of difference for her personally (but I know it helps a lot of people). Supplement wise DAO was the most useful for food truggers

I found H2 anti-histamines like Pepcid actually made my symptoms worse.

I was in a similar situation where Claude finally helped me make a breakthrough. It seems that my issue is entirely related to histamine levels.

* H1 (like Zyrtec) help block the body’s response to high histamines

* H2 (like Pepcid) actually worsen my symptoms overtime because my body was readjusting baseline

* Quercitin and DAO enzyme help massively.

Also being extremely mindful of histamine levels in food helps keep my baselines low. This can be tricky because histamines collect as food ages (so two batches of something can lead to different responses) and some “low histamine” foods can still trigger your body to dump histamines (so they actually act like high histamine foods).