- https://lite.datasette.io - my Datasette app in a browser
- https://simonw.github.io/research/pyodide-asgi-browser/datas... is a new, improved version of that using Service Workers that's still a little experimental - notes here: https://simonwillison.net/2026/May/30/pyodide-asgi-browser/
- https://tools.simonwillison.net/micropython runs a MicroPython playground in the browser via WebAssembly
My use-cases for server-side WASM Python are described here: https://simonwillison.net/2026/Jun/6/micropython-in-a-sandbo... - basically I want to offer end-user customization features that run custom code without buggy or malicious code crashing my app or leaking their data.
Once you get away from running in a JS environment or away from code that's written with the intention of running in a WASM sandbox, if you don't want to have to modify the code for your environment then you're going to start having problems. This looks like a good step for anyone wanting to run arbitrary Python outside of a browser environment.
I've been doing a bunch of work recently with iframe sandbox combined with CSP which appears to be a robust way to do this.