> and less likely to be high always while programming

It depends on the drug. If you're an amphetamine/meth addict (or other designer stimulants), you very well might be coding for days on end. I certainly was.

It will even get to the point where you feel dependent on them to focus and "get things done", like being sober is a handicap.

Not really.

I'm a recovering addict, felon, and have depression (lucky me). And though there were times where I could work an entire weekend without stopping, it was always followed by 2-3 days of doing absolutely nothing because I was so dope sick/depressed. The worse my addiction got, the shorter the "flow" period and the longer the recovery period took.