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I was reverse engineering a medical device, and had to do a lot of trickery to get Opus 4.5 - not even Fable/Mythos, Opus - not to trip up its fucking CBRN filter.

What happened with Fable is basically what I feared when they announced those restrictions. They took the shitty Opus CBRN filter and made it even worse.

I pity the fools trying to use Anthropic AIs for anything biotech.

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Opus has been fine on proteomics and bioinformatics for me. I have never seen a Claude model refuse on such grounds before in the past.

Claude is still the best IMO, but it feels like its most frustrating and grating aspects are not down to the model’s abilities, but the increasingly heavy hand of Anthropic expressing itself within the model. Fable’s comically useless responses almost seem like a cynical marketing tweak.

“This model is so powerful we basically can’t let it do anything. How terrifying! We need more money to make it stronger. Now do you see why we should be the ones who write the regulations? We’re the Good Guy AI Company Who Will Never Ever Ever Be Unethical after all.”

As this entity gains more ground, their models become increasingly annoying to use and their little act becomes more transparent. The whole “I’m-just a befuddled ethically-minded AI researcher who is perturbed by the power that I unwittingly discovered and I must warn the world” thing? Yeah fuck off. Your twee pandering to naïve nerds and cynical technocrats is nauseating and ordinary people can smell it a mile away. Completely repellent leadership who put up red flags to anyone left with a working ability to read between the lines of both spoken language and body language. The tech company equivalent of a sex predator who plays as the nice guy. Gross.

Nobody likes these companies and their models are annoying, but we’re going to put up with playing middle manager to these obnoxious programs because our jobs depend on it now, and these products are still the best on the market.

A breakthrough in tools that facilitate user-owned models and infrastructure is desperately needed for the sake of our dignity and sanity, if nothing else.

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My personal suspicion is that it went "medical hardware -> high-throughput screening -> biorisk" in that old Opus case.

I like Anthropic's work, and I would be the first to argue against all the usual "it's all PR" whine. But there is a limit. And whoever made those fucking filters needs to be fired out of a cannon into the sun.

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The filters are really bad.

Yesterday Fable rejected commenting on poetry because it had anatomy lines like:

got anotha round of acetylcholine from da boss.

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