Edit: relevant Scott Alexander article from today
https://www.astralcodexten.com/p/my-ai-opinions
> In terms of bioweapons, I expect that closed-source AIs will be heavily optimized against helping with these, and open-source AI will be banned after the first warning shot (or become economically prohibitive even before then).
(For example, I suspect that plenty of folks would view the recently threatened mass scan of the DN42 hobby network as an instance of misaligned agentic behavior that would have wasted non-trivial resources, and I also think that most observers would pin the specific behavior of that AI on a proprietary SOTA model, not an open one. That's clearly not a disaster-level event, but it should scare you if you're concerned about alignment.)