With EPUB compatibility issues CSS should always be suspect number 1. Using "modern" CSS features and complaining about missing flex boxz grid, etc is a web developer's mindset.
Just because EPUB shares some of the stack with the web doesn't mean they perfectly overlap (or even should).
Hardly any e-ink embedded e-reader devices use a browser for rendering, they all use purpose built HTML/CSS parsing and rendering toolchains, are baked into firmware and updated once in a blue moon. (If you're interested look at koreader's crengine or Crosspoint reader which runs on an ESP32!)
The blog post reeks of overly confident AI prose. But don't be fooled.