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Fusion 360 complains about Windows 10, but it still runs fine.
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I'd say that comes down to the difference between requirements (i.e. will it run at all, does it use features only found in win11) and support, and the developer's decisions around that. I can appreciate not supporting win10 even if it runs as they have a written or implied burden to make sure it keeps operating correctly for the lifespan, and that may include keeping test systems around or handling bugs that turn up in the OS that's getting reduced support itself, or other factors like drivers. Then there's the question of whether people would be willing to pay for a "your mileage may vary" level of support on something commercial.
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