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The same could be said for a lot of drugs that have strong side effects, just one difference here is the main "side effects" are something some people consider fun. Though you could still do double-blind for comparing the effectiveness of different psychedelics, e.g comparing LSD to Psilocybin.
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Niacin works well as an 'active placebo'.
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just because it's not double blind doesn't mean it's not science though.

like idk, how do you do double blind studies of astronomical phenomena?

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Yeah I know. I'm pulling that out as an example.

It's also true that people in the psychedelic world talk about non-reproducible aspects of the trip quite a bit. "Set and setting" and so forth.

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> just because it's not double blind doesn't mean it's not science though.

Shhh, non-scientists don't know that.

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Double blind studies became a requirement in order to protect the people from the greed of pharmaceutica companies and their natural desire to cut corners in research.
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