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On my MacBook I map the right hand command key to “ctrl” and the right hand option key to “meta”. Since the command keys are right next to the space bar that puts the ctrl key on a thumb position most of the time, and for the times when that isn’t a good key for a given combo I still have caps lock bound to “ctrl” as well. Seems to work reasonably well and lets me keep the usual command and option keys on the left side for “super” modifiers and for typing accented and other characters.

For my desktops, I use an Ergodox EZ keyboard and mapped ctrl and meta into the thumb clusters there.

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Don't use your pinkie or any finger. Use the meat of your hand to hit the control key.
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This works especially well on an IBM Model M because there's nothing in the vicinity of either the left or right ctrl, you just chop your palm down and can't go wrong. I could also pretty reliably M-x in one hit by flipping my left hand over, curling my pinkie finger, and hitting the keys with the knuckles. On more crowded keyboards I remap ctrl:nocaps and use thumb and forefinger for M-x. I actually deliberately got rid of my Model M to teach myself to do it this objectively worse way, because context switching between my docked workstation setup and laptop keyboard on the go was difficult. If only someone would make a laptop with a proper keyboard...
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