The great virtue of the in-band challenge types is that web servers can just handle them out of the box, without any need for a separate setup step that depends on your stack. I think this has done a heck of a lot to increase adoption of HTTPS.
Also, DNS-PERSIST-01 seems to be coming soon for Let's Encrypt, which should allow even people that can't easily dynamically update their DNS records to get wildcard certs. I assume this might become more widely used than HTTP-01 challenges.
I wish someone would write a blog post about the difference between DNS registrars and DNS hosts, because I've seen people assume they need to use a registrar that has an API in order to change their DNS records programmatically. I used to assume that too.
- registrars control NS records, however these can be changed
- NS records control other records
- registrars can also use their own nameservers to manage your DNS