For example, Imagine you have an api like `void do(List<Foo> foos)`. In the erasure environment of the JVM that looks like `void do(List foos)`. From python it's pretty easy to call with a `foos = [Foo()]`. But not so much if your python implementation needs to figure out how and if it can coarse it's `List` type into a `List<Foo>` type.
Having reified generics in the CLR just lets you store more type information. There isn’t much of a trade off for CLR end-users.
Compare this to the constraints and workarounds that Kotlin and Scala have due to type-erasure on the JVM.
The creator of Scala disagrees: https://youtu.be/Xn_YpUtXWT4?t=850
And as far as I'm aware, both kotlin and Scala don't really suffer due to type erasure.
That being said, it is easier to write a language on top of the JVM with good interop, since there are less ways to implement features. Essentially, your language has to interop with Java.
And it is harder to have good interop between CLR languages because there are more ways to implement features. Essentially, your language has to interop with C#.