Sciter SDK [1] contains scapp[.exe] - standalone Sciter engine that can be attached to HTML/CSS/JS bundle making standalone (single exe file) and portable executable. https://quark.sciter.com/ tool allows to compile such apps.
Size of "hello world" is a size of scapp.exe binary + size of compressed HTML/CSS/JS bundle.
On Windows scapp.exe is of ~14 Mb. On Linux ~18 Mb.
Linux version at startup detects GTK4, Wayland or X11 and uses those as windowing backends.
On all platforms Sciter provides out of the box: HTML/CSS/JS runtime, libuv based Node.JS alike runtime, GPU accelerated rendering, WebGL 3D runtime, JS built-in persistence (NoSQL DB).
It does not have TS compiler built-in as Deno, but that TS-to-JS compiler is better to be outside anyway as it is used only once - at app loading.