Yes, but it turns out the hump is great for area ruling (aerodynamic drag reduction at transonic speeds), as observed by the 747-300's extended hump giving lower drag (but higher weight, of course) than the short-hump versions.
Me321/323 was I think first heavy cargo with nose clamshell doors, but after that everyone settled on nose rising up, clamshell rear. It also had the top deck.