The things you can't do are things like expose an accessibility tree (without a dummy DOM), interact with the system IME, and access system fonts.
Even input you might be able to hack around but accessibility is a big deal and the "hack" at that point is nearly to both lay it out in the browser and the supposed "fixed" layout system, and while that may work in some sense I again have lots of questions about whether that is really "fixed".
FWIW, I actually think it would be much more valuable just to fix the spec and make CSS layout fast-by-default.
Nobody else seemed convinced :(
The reason why I consider it a possibility is that LaTeX has two things out of the gate: The technical capability, and a small but arguably rabid user base. It's the sort of thing that can take an early lead but is quite unlikely to sustain it.
But you can't deny that LaTeX has had incredible staying power, despite the list of issues that everyone who uses it has with it.