Rest time of a couple of days is good. I'm not talking about that.

But more than a week and you'll typically need to deload to avoid DOMS. More than a few weeks and it will start taking significant time to work back up, and a lot of injuries happens because people try to rush that recovery and add even more time to that.

If you regularly lose weeks at higher age, it quickly becomes tricky to avoid tipping over into lasting decline.

The only problem with time off is it breaks habits. a couple days off and suddenly you haven't done anything for months.