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> Anecdotal, but I'm convinced it screws up sleep quality.

It absolutely does.

>I'd just accepted for the longest time that waking up groggy with a slight headache and tired was the norm until I put a CO2 monitor in my room. With the door closed, it climbed up to 1500ppm in under an hour.

Same experience here. Opening windows just a bit totally changed my sleep quality.

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Higher CO2 vs. free cat access at 4:17am. No win scenario!
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I have this same challenge!

Also, moved all of my lovely oxygenating plants like lillies out of the room because they are toxic to kitty.

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And window.
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An open window means kilowatts of energy wasted. All the air I spent money cooling will just leak out. It also means all the pollen will be let in.
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