>Operation Sea-Spray was a 1950 U.S. Navy secret biological warfare experiment in which Serratia marcescens and Bacillus globigii bacteria were sprayed over the San Francisco Bay Area in California in order to determine how vulnerable a city like San Francisco would be to a bioweapon attack. There has been speculation that the experiment may have contributed to one death and at least ten illnesses.

Wow.

Also, despite GP's dismissal of the "low-hanging fruit" hypothesis, it is obviously true that we've found the easy-to-discover drugs, and therefore drugs would get harder and harder to find.

A flippant dismissal in an HN comment does not actually negate reality.