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You can mix and match to some extent, though Nanite, Lumen and Megalights are intended to work together. Megalights really needs Lumen, and Lumen works best with Nanite.

There’s the whole forward renderer path you can use instead, which works well on lighter hardware. Or you can use baked lighting instead of Lumen, and some people have created other realtime GI systems as plugins.

You can’t really change the material-shader pipeline though without overhauling the entire engine.

There are also a ton of parameters and configuration options you can change. These can be quite obscure and this is where small studios struggle.

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You don’t need to flat out replace the render pipeline to get a wildly different look, a single new native render pass is very achievable (and if you have the skills to write your own renderer you absolutely have the skills to modify Unreal’s)
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A unique look is 99% art direction.
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