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> to detect an effect significantly stronger than most drugs..

What the heck are you smokin? Did paracetamol have a weaker affect on temperature than smoking causing cancer?

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That is correct. Smoking has a stronger effect on cancer rates than paracetamol does on fever (which itself is an extremely strong effect that can be proven in RCTs of just a few dozen people - far stronger than most drugs on the market).

Thank you for demonstrating my point.

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And thank you for demonstrating mine..
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