> RF drone detection has been a challenging problem for quite a while.

Correct, there is no bullet proof cuas system to this date.

> anything flying autonomously is even harder to detect

Not just autonomously, because even in autonomous mode you would still need other RF like gnss, but you can fly drones without any rf signature at all and utilize a pre captured images saved on board to navigate the drone accurately using its cameras (normal or thermal). In this case, rf interference won’t work, it won’t be detected based on rf signature either, you will have to rely solely on visuals and acoustic, fly at night, and only left with acoustics.. it is a very hard task from technical standpoint.