Dark matter is a great example.
Our understanding of gravitation didn't cleanly apply at ultra-large scales so we had to add a massive fudge factor.
You can't "go faster" than the speed of light, but space in between things can expand faster than the speed of light.
It seems like things that are "settled" regularly get an "ope, but except for this special case..." treatment.
I’m not a physicist, so I’ll let them pipe up on how much is in and out of the descriptive line, and how much is in and out of the theoretical explanation line. But I don’t know many physicists who think we’re close to “done” with either endeavor.