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As early as the late 19th century, Louis Pasteur’s work had inspired a belief in the scientific community that it must, in principle be possible to selectively exterminate bacteria. The German physician Paul Ehrlich expounded on this in greatest detail in 1907 when he described his “magic bullet” (or Zauberkugel) theory for effectively targeting pathogens without harming the human host, similar to the immune system.

However, if you had had demanded someone for a blueprint in 1925 of how to design such a magic bullet, especially a magic bullet that targeted virtually all forms of bacteria, it would have sounded ludicrous. Yet, 20 years later, the world was manufacturing 6-7 trillion units of penicillin a year, capable of treating 3-6 million people. And that’s in spite of the fact that Fleming’s work sat mostly untouched for a decade before Howard Florey and Ernst Chain seriously set about to isolate and purify the substance.

You can quibble and say that penicillin was discovered, not designed, which is certainly true. But I would ask you to consider, does current AI development look more like design or discovery? Does it look more like analytical engineering or evolutionary selection? I would say on both counts the latter, in which case, we should prepare to be surprised how long it might take to make revolutionary advances. And that’s on both sides of the ledger, we might find ourselves stuck in the current paradigm for a long time. But, we might not be.

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Yes I think the drug discovery analogy is apt. I've spent a bunch of time playing with evolutionary algorithms, they're great fun. And when they work they can do surprising things! [edit] I think the drug discovery analogy does have some limits though. Drug discovery isn't a blind search through fitness space, it's informed by physics, chemistry, biology, and medicine. We have many guiding lights to illuminate the space and identify regions (still high-dimensional infinite regions!) that are likely to be productive. There are fewer lights to guide the way on a search for fitness in intelligence. Hell, we don't even know how to write down a decent objective function.

I wouldn't bet on evolving an intelligent, sentient being-in-a-box on a computer any time soon though. I'm of course prepared to be pleasantly surprised.

That said, I think it's pretty clear that LLMs are not going to get us there.

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I don’t think people are arguing to stop researching AGI. Moreso against sales people trying to use the concept of AGI to sell products that are very much not AGI. Or devoting so many of our resources into such a pursuit that it causes harm to real people.

This is obviously complicated by the fact that LLMs/Agents are useful by themselves, but that’s not really the topic at hand.

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The parent poster argument boils down to "[something] is theoretically possible, therefore 1) it is guaranteed to practically implementable 2) in the reasonably near future". Both are simply prima facie false; one can ask an LLM to explain why if there's any doubt.
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And now we’re desperately trying to ”upgrade” penicillin (and friends) because it doesn’t work any more in many cases. Do you think we can repeat the process or do we need something completely different?

This is why biological comparisons are weak, we talk about a few agents verifying and checking LLMs, meanwhile the world consists of almost an infinite number of the same, just operating on different time scales. I agree that with we don’t know the timescale, and we definitely don’t know if long term it will continue to work ”adding more of the same”. Throwing more penicillin at the problem sure as hell didn’t, but it looked great initially. And I’m obviously not arguing the human benefits of penicillin, just that what we thought would work forever quickly didn’t.

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To quote the great Dr. Malcolm:

> Life, uh, finds a way.

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No one imagined LLMs in their current format, it was simply a result of discovering that scaling compute and tokens produced better and better results with the Transformer architecture. The inventors of the Transformer architecture were working on better translation, and probably did not imagine that their architecture would lead to modern LLMs.

Imagining something in advance is not necessary at all for scientific advancement. This is particularily true in AI, and no one expects to imagine what superintelligence is until after it is created. You set up your datasets, your architecture tweaks, and measure the results on some set of benchmarks. There never was a blueprint, no plan beyond the experiment itself. We're not even close to understanding the things we have already created, and yet we created them. So why expect anything else for the next step?

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<< No one imagined LLMs in their current format

That is simply not accurate. There are examples of scifi novels, novellas and other media that dealt with it. We can argue over whether it was that exact format, implementation and so on, but that 'shape' ( to use a common llm term ) of technological advances was very much explored.

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> Imagining something in advance is not necessary at all for scientific advancement. This is particularily true in AI, and no one expects to imagine what superintelligence is until after it is created.

Then why does anyone expect to create it? I'll take a stab at an answer: they think an LLM is some kind of "incremental improvement" and therefore a step along the inevitable path to discovering AI. But that seems delusional to me. I can't imagine anyone sound of mind who knows how an LLM works thinks it's actually intelligent. So in what sense is it an "advancement" on the path to AI?

The concept of an incremental improvement in an objectiveless search in a high dimensional space is.. absurd.

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> actually intelligent

It's reasonable to doubt that LLMs are a path to AGI, but I don't understand how this is still a matter of dispute in 2026. What's your definition of intelligence that doesn't cover an entity that can translate fluently between dozens of languages and also solve open problems in mathematics? And be real-if you have one, is it a definition you or anyone would have given a decade ago, or are we doing "god of the gaps"?

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I can't give you or your sibling a better answer than "you'll know it when you see it". Some people see it now. I think they're wrong, because it seems like the results you're describing are easily explained by fuzzy search in the space of embeddings and then forming strings of plausible tokens related to the resulting region of embeddings space. In other words, the things we know LLMs actually do.

That's more or less looking for interesting patterns in a jpeg or another lossy compression result. It's interesting that the models seem to be able to (fairly) reliably return relevant chunks of the image. Even more interestingly, they seem to be able to invent plausible chunks of image that aren't even there. That doesn't meet my bar for intelligence though. I'd need to see it learn and adapt. I'd need to see it be clever, not merely "knowledgeable". I'd need to see it capably analyze itself. I'd need to see it reasonably estimate uncertainty and know itself in the sense that it has some idea how right or wrong it is about something. I'd need to see it exercise judgment.

I don't think I'd give a different answer a decade ago but who knows.

[edit] For all we know, one of the salient features of intelligence is that intelligent beings are incapable of precisely defining it. I'm not sure how productive it is to attempt to do so.

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I appreciate the straightforwardness, but you probably understand that's pretty unsatisfying.

Actually, stronger - it's valid in some circumstances to say something is infeasible to precisely to define and you'll just know it when you see it. But I don't think it's reasonable to take that stance and then assert that "anyone sound of mind who knows how an LLM works" must agree with what you see. You gotta pick between striving for rigor and denying your opponents' soundness of mind.

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What is your definition of "actually intelligent"? I believe LLM's are more intelligent than the average human in a lot of ways according to the Legg/Hutter definition of intelligence: "Intelligence measures an agent's ability to achieve goals in a wide range of environments".
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In this very thread I am being told that Fable is nothing but a bit of scale and refinement on well-known neural network techniques. And next I am told that we can't even imagine how to build superintelligence. Which is it folks?
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