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This finding of shingles and dementia is likely due to “healthy vaccinee” bias as per the link someone else posted below:

https://youtu.be/qlTnnQytOJ0?is=XJ0c5pWVV6Lg0IMs

As per one of the slides around 7 minutes in, there are many vaccines that show a 20-40% reduction in mortality and dementia.

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I read before that iirc because of waning protection it’s better not to get it too early. It’s not clear to me why you can’t get it twice, but what I read (and it was some online discussion so could be wrong) was that someone had been specifically told by their doctor to wait to 50 as the best spot to get it. I’d like to know more, I’m in my 40s and would be happy to get it now too but not if it was going to be worse overall for some reason.
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My primary care suggested I hold off to mid-late 50s instead of right at 50 for this reason. Between not wanting shingles, and some of the newer research into neuroprotective angles I'm not sure I'm going to do this however.
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But surely you can do a booster shot?
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So far as I know there's no standard booster protocol for Shingrix.
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That just tells you it hasn’t been fully researched, not that it wouldn’t be useful.
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The antibodies you develop to fight the virus fade over time. I just had it fairly recently (young 30s, vaccinated with the attenuated chickenpox virus, never had chickenpox, so this was likely the vaccine strain¹). Did a lot of reading and research during and after. The antibodies seem to offer good protection for 5-10 years following either vaccination or infection according to the literature I was reading.

¹ The vaccine strain tends to be much more mild than the wild strain, and indeed it was quite unpleasant, but not extremely painful for me. The wild strain is considerably more painful and linked to a greater incidence rate of complications. Please do not skip chickenpox vaccinations for your kids, the minor risk of latent infection from attenuated vaccine is far less harmful than the consequences of not vaccinating. Most important of all, if you have a cluster of blisters or rash on one side of your body that keep popping up, make sure to see a doctor and get on antivirals within the first 72 hours for best results.

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You had Shingles after never having chicken pox except the vaccine?
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I feel like we've probably spent more for less! Any interaction with the medical industry for less than 1k feels like a steal to me.
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There were a few studies around 2022 showing the influenza vaccines and pneumoccocal vaccines reduce alzheimers (influenza by up to a whopping 40%!).

I tell me patients this to increase uptake, so we can reduce alzheimer's prevalence.

(I'm a doctor)

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My understanding is that they're not sure if the vaccine will last in your system for more than 30 years, and that subsequent doses may be less effective, so getting it early may weaken you later.

But I am with you. My personal bet is we'll know more about this by the time that becomes an issue.

The earliest cohorts of vaccinated children are approaching their 30s, so we should learn about long term efficacy this decade.

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While we're on the topic of vaccines: if you were vaccinated against measles before it switched to the two-dose schedule (1989 in the US), you might want to have your titers measured.

I was vaccinated in the early 70s when it was a single dose. With measles in the news recently, I asked my doc to add a measles antibodies test to my blood draw. Came back negative. No immunity. I went to the local pharmacy and got an MMR booster the next day.

https://www.health.harvard.edu/diseases-and-conditions/some-...

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Wait, you can just pay for the shingles vaccine, before you're 50? Where do I do that?

I had shingles in my 30s. It was the sickest I've ever been.

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I'm in my 40s and asked my GP for it since I similar had a bad experience with it a few years ago. After warning me 3 times that it might not get covered by insurance, they gave it to me. I tried to get the second dose at a pharmacy, and they would not do it since I'm under 50. I got the second dose at my GP again a few months later.
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You can get basically any medication or vaccination you want in the US as long as you can find a doctor to write the prescription.

We even have anabolic steroids that were approved for muscle wasting in cancer patients, but if you can find a doctor willing to write the prescription and a pharmacy that won’t question it, anyone can have pharmacy grade Anavar for the gym, completely legal. In theory the doctor writing the prescription is putting their license at risk, but enforcement is so lax that there are “anti-aging” clinics all over that will prescribe testosterone and Anavar to anyone with a credit card.

So with a documented history of shingles you should have no problem getting a prescription written. It would be worth a quick check with your insurance company because it might even be covered if your doctor will fill out the form and attach evidence of the past diagnosis.

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> You can get basically any medication or vaccination you want in the US as long as you can find a doctor to write the prescription.

Is that not usually true in other countries?

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Not exactly. My doctor wanted to start me on a medicine that would make me more likely to develop shingles so he asked me to get the vaccine series before he'd prescribe the medicine. I guess there's no such thing as a prescription for a vaccine, so I just went to my local pharmacy. I made the mistake of writing on the form that I had no health issues. The pharmacist came out and said because I wasn't 50 and had no health issues they weren't allowed to administer the vaccine. Even after I explained my condition and the doctor's request they still refused. They wouldn't even let me fill out a new form. I had to go to a different pharmacy which conveniently didn't ask about my current health status.

It's stupid too, because the question I answered "wrong" wasn't clear. It basically sounded like they were asking me if I currently had a cold or covid.

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You can just ask for vaccines at the pharmacy. I got a potentially missed childhood vaccination as an adult and they asked a few questions about why I wanted it, but were happy to give it to me. If it’s something odd you might need to go to a travel clinic.
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Not this one you can't.
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I told my local Walgreens I am immunocompromised and they did not ask for proof (early 40s).

https://www.cdc.gov/shingles/hcp/vaccine-considerations/inde...

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See this is the information I'm looking for. :)
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Happy to help!
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If you have already had shingles as an adult, aren’t you fairly well protected for the next ten years or so, at least? I’d wager that you are one of the people least at risk since your immune system is already primed and readying suppress the virus that’s latently infecting you.
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You are more likely to have a recurrence of shingles after once having it before. At any rate, I had mine more than 10 years ago.
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If you just want to pay out of pocket or with an HSA, etc. you can get many vaccines at a pharmacy. Might need to check if there are limited hours for that service or appointments needed. Not sure if Shingrix is one of them.
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I've tried to get the shingles vaccine at Walgreens before and been turned down because I wasn't old enough.
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Huh. Well maybe not then. Did you make it clear you'd pay out of pocket and not insurance?
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Yes. I really want this vaccine.
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Have you tried asking your PCP?
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I'm pretty confident I could talk my PCP into it! I'm just wondering if there is some easier retail way to do it.
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I got shingles at 45 and it was -not fun-. My arm is slightly disfigured.

I think the age 50 target is dated. With reduced childhood incidence of chicken pox, we're all exposed to varicella zoster less, and it seems like the ages of incidence of shingles is falling. Public health recommendations are slow to catch up with research (especially for vaccinations, these days).

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I got it around 36, and coincidentally a friend 5-6 years younger than me in a different part of the country got it at the same time.

My research at the time led me to the same conclusion: Since we've basically eradicated chickenpox, we're not exposed to the varicella zoster virus as much as previous generations (via children that have chickenpox). Without exposure our antibodies / resistance fade out.

Since we had chickenpox, the virus is already in us and dormant. When it wakes up and decides to do its thing, our bodies have forgotten how to fight it effectively compared to previous generations - and as a result, the incidence of shingles is increasing in younger populations compared to previous generations.

My doctor said vaccination for under 50 is only indicated after multiple occurrences of shingles... so here's to hoping I'm good til the guidelines change.

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> Japan was among the first countries to vaccinate for chickenpox. The vaccine developed by Hilleman was first licensed in the United States in 1995.[17][60]

People (well, Americans and Canadians at least) in their 40s now generally didn't get vaccinated as children, as their parents didn't have the option. It will be different for the next generation.

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Interestingly UK took a different approach and only started offering chicken pox vaccines for children this year.

https://www.gov.uk/government/news/free-chickenpox-vaccinati...

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Which, if chickenpox is really the cause of a lot of dementia (as this article implies) might have been a pretty grave mistake.
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Yeah, I came here to say the same thing. I got it around 46. The horrible looking stuff on the outside is also on the inside, and it weakens your internal tissues. I know this because I tore one of the muscles in my lower back, and it still causes problems.
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Shingles terrifies me because it can cause hearing loss. I spoke to my GP and he wouldn't give me a script for it even though I'm 3 years away from qualifying. He mentioned side effects.
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"An increased risk of Guillain-Barré syndrome (severe muscle weakness) was observed after vaccination with SHINGRIX"

https://www.shingrix.com/side-effects/

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That seems like being penny wise and pound foolish.
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Looks like the GP is in the UK.

I tried to go private (also not 50), but everyone just refused. Pharmacy, GP, private GP.

Currently I'm arranging it in the third country because WTAF.

(UK becoming the dirtiest and sickest country of Europe one more time)

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The age for shingles vaccine in the UK under the NHS (so free) is 65.

Of course I got shingles when I was 64. Caught early and got anti-virals and had no lasting effects.

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> (UK becoming the dirtiest and sickest country of Europe one more time)

Big Yawn

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I think the bigger thing is that the vaccine has a peak response window, and the current medical guidance lines that up with when you're epidemiologically most likely to experience a shingles outbreak (for most people, that's very unlikely when you're young, because your immune system is so jumpy, but that wanes with age). If you get the vaccine early, its effect can be attenuated right when you need it most.

(I don't like this logic and if I had the option of just going to Walgreens and getting vaccinated, I'd do that this afternoon. I'm just saying, there's a logic to it.)

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My A1C popped high, so I could get Shingrix 2 years before the nominal minimum age, paid for by insurance, on the technicality of having a T2D diagnosis. My blood sugar is much more under control now, but that's a nice little side benefit I won't hesitate to take advantage of. The most severe side effect for me was long term muscle pain near the injection site (even now 10 months after I got the shot). But it's totally worth it because the pain of shingles is far, far worse as I understand it.
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aside from age ranges being the tested population, your just gambling no other interference pattern is involved.
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