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>Replicated association [...]

"association" undersells it a bit, because the data is better than the typical cohort study, which has issues like "what if people who got the vaccine are also richer and care about their health more?". There's quasi-randomization going on. From the more in depth article that's linked:

>Research is also revealing unexpected interventions that help to keep ageing minds sharp. One of the most promising derives from an analysis by Pascal Geldsetzer of Stanford University and his team of a natural experiment in Wales. In 2013 the British region started offering people aged 70-79 free vaccinations through the public-health system. This change resembled an RCT, in that a large number of people were separated almost at random into two groups: those who had already turned 80 in the weeks before the programme started, and so were not eligible to be jabbed; and those who turned 80 in the weeks after, roughly half of whom were duly vaccinated.

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I wonder if infections do not cause more dementia, but are simply correlated with more. A weaker immune system may trigger many many things.

And similar questions about obesity "causing" many diseases, sunburns causing skin cancer (although that sounds somewhat plausible) etc.

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There isn't a causal mechanistic link between shingles and Alzheimers. We don't know why the Shingrix vaccine reduces incidence of Alzheimers.

(You should very much want to avoid any chance of getting shingles, though; it's a nightmare.)

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The shingles virus hides in the nervous system and can come back out when immune control weakens. It causes inflammation and nerve injury, sometimes severe enough to leave people with chronic pain. From there, it’s reasonable to theorize that it could also affect the brain and even its glymphatic system over time.
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I'm one of those people (knock on wood) who never gets sick. I never get colds or seasonal flu, and I don't get routine flu vaccines. Never got COVID either, even when several people in the house had it (I did get the J&J vaccine for that, however).

I did have chicken pox as a kid, but have not had shingles nor the vaccine (yet). A co-worker was laid up for a week after his shingles vaccine, but that's obviously just one data point.

But, I've been considering getting the Shingrix series even if I have to pay for it. I turn 60 this year. Shingles doesn't sound fun.

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Just curious, do you have children? Do you socialize pretty freely during all seasons indoors?
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> like the more colds you have in life

Whoa wait what? This is the first time I’ve heard of this - is this actually common knowledge?

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Not common knowledge, but should be in this day and age. For example, someone who worked in daycare and often got sick with the flu or similar, has a higher risk of dementia (statistically-speaking).

When I learned it, it was in the context of the influenza and similar common viruses.

It's actually more nuanced than that. If you want to read more: https://www.openevidence.com/ask/bccc3cc2-e15d-4fb0-a0c5-16f...

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As far as I know you're overstating what is known.

There was a study that showed that people who had severe influenza (they were hospitalized) were 3 times more likely to develop dementia. And there are mouse models that show that frequency respiratory virus infections can increase may contribute to brain aging (in mice).

>someone who worked in daycare and often got sick with the flu or similar, has a higher risk of dementia (statistically-speaking).

I can't find any evidence of this being true. I can find evidence that primary school teachers have lower rates of dementia. Pediatricians also have lower rates of dementia, so I find this highly doubtful.

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