Drug holidays can make a small impact, but tolerance is going to build to many of the effects no matter what you do.

The other problem with drug holidays is that some people start getting into cycles where they don’t take the drug and have lazy days where they justify not doing anything, then they wait for the drug to kick in on the return day to even try doing anything. The housework and personal life things pile up on the off days and then they try to speed around and do it all on the medication days, which is another pattern that isn’t sustainable forever.

Drug tolerance doesn’t build and then abate in a very asymmetric manner where someone could take it for 30 days and then have a couple days off and reverse it all. Some of the biochemical mechanisms of tolerance have persistence measured in months or years.

If you feel you're getting tolerance to amphetamines, the first thing to try is magnesium glycinate/threonate supplements, and then hydration and diet and sleep.