I was about to say the same thing..
replyI use a dual A7X setup with a Sub10 Mk2 in a proper studio listening environment, and I can easily hear the difference between a low‑quality MP3 and a fully lossless WAV/FLAC. I do have trained ears, but even an untrained listener could probably notice that level of difference.
Define low-quality. Encoded at V[0-2] with a recent LAME, I doubt the difference is more than ABX nitpick material; and that despite MP3's inherent limitations (like https://wiki.hydrogenaudio.org/index.php?title=LAME_Y_switch...).
replyI use a pair of calibrated Genelec 8341 btw.