Oh for sure, doing any otherwise would lead someone to psychosis very easily. Coming from a family of MDs and being educated in multiple scientific fields myself, I still don't have an answer. But one thing for certain, you have to disregard everything, including religious beliefs and go by the scientific method.

There are tell-tale signs that people will tell you to ignore like fasciculations (muscle twitching) noticeable with the naked eye which are a signs that neuro transmission is peaking more than normal (that would be glutamate-linked).

The problem is that people don't have an answer even after doing Root Cause Analysis. Leaves you like someone trying to explain how the sun looks to someone who is blind.

Occam's razor.