How long's the longest voyage these days?
Mutinies aren't so common nowadays, but they were when ocean voyages were measured in months and years.
Not really, unless you're obsessed with the idea that great works need to happen within your lifetime. Europe is chock full of cathedrals that took 400-600 years to build, worked on by countless generations who would never live to see them completed.
Unless we have generational ships the size of small countries, I'm not sure the human brain - unaided and non-forcedly evolved to do so - would be able to handle essential incarceration in a series of metal tubes for its own and its descendents existences.
Like, to get a useful amount of people to Mars would be... the wealth of a first world nation for tens of years. Even using nuclear engines.
A generational megaship travelling at some small percentage of c to a nearby useful star (not even the nearest ones, which are all a bit shit)?
There's just nothing within our current projected reality that could even begin to accomodate that possibility.
Never mind the fact you'd need redunancy, and at least a few hundred years of testing to ensure that whatever mega project you could ultimately send wouldn't simply get vaporised halfway through, from realities unknown.
Provided the Earthlings that were sent along don't let their incarceration induced insanity infect the youngin's.
Future AI and a database of all of humanity's experience before launch might be enough to keep the generational populace amused and distracted for the entiriety of their meagre, trapped existence... .