5.6-Sol is a lot more permissive than Opus/Fable even w/ CVP (once you sign your soul away to Palantir via Persona, anyway), while maintaining better capabilities
5.6-sol in a single prompt was able to discover a zero-day in a web application (with no sourcecode provided, only known api urls) and I do not even have /cyber verification on my general purpose account. I wasn't even really tryign to "find" a zero-day it was just looking for bypassing a restriction... Instead of spending 10 minutes filling in a form I ended up having to spend an hour drafting a report and sending an email.
So I guess the new opus will not run on my drug discovery project. It's just a binary classifier to screen for new malaria drugs. Fable completely have up on that codebase citing bio security concerns. Seems like this domain will go unsupported by Antropic
I do want to add, that I am pretty bummed if Opus 5 is going to refuse the tasks I have been using Opus 4.8 for (neuroimaging). Fable absolutely refuses anything close to toughing neuroscience.
I found the biggest problem with fable is the random reasoning_extraction refusals as well as cyber refusals when it sees hex because only hackers use hex.
Anecdotal, but I tried running a few identical biology questions through both Fable and Opus and the classifier was only rejected my queries with Fable.
This is good news. I'm doing a lot of work that Fable thinks is AI related right now (it is nothing remotely competitive to Anthropic - it's just relatively basic stuff I'm doing with learning models and so forth), yet it blocks me almost every time. I have switch to GPT-5.6-Sol for this work since it's stronger than Opus 4.8.