Most Francoils I know don’t have a way to get rid of any condensation that happens in the unit like internal air conditioning units do. So even if you run the piping outside of the house you have condensation in the unit and the floors, not to mention the walls.

Even then, there is a fair limit in cooling and efficiency you can get from them because of the lack of phase changes occurring.

If you have a balanced mechanical ventilation (both inlet and outlet) that would be one of the best options to condition the whole house without putting air conditioning units everywhere. Having said that, we turn on the air conditioning in the attic during hot days which removes the biggest heat and moisture from the house. Next up is installing more sun blinds to prevent the heat from entering in the first place.