Just my experience though, I'm still figuring things out. Perhaps some subsets of tasks would be more ideal for these long-horizon workloads - exploration, multiple competing implementations, etc...
I left something gargantuan running over the weekend (decompiling 1980s-era system software) and look forward to checking it out later today when I have a few free minutes.
Given the hardware shortage in the world, I suspect renting ("sharing") via APIs will likely remain cheaper for the foreseeable future since each piece of hardware isn't sitting idle nearly as much.