I meant "fully scientific theory of harmony" in the same way your second paragraph does, not as predictor of popularity but predictor of what kind of effect it raises in the listener. A big part of how music effects the listener is sociology, which sure is scientific, but I tried to use scientific in the way the article uses the term, IE from objective first principles and not culturally specific/learned response.

It's worse than that though -- the things that you are born enjoying, are loud oceanic white-noises and a deep thumping backbeat with occasional muddied high-pitched vocals.

I had a similar dream as a freshman in physics, I had learned that the organ of Corti was a spiral-shaped transducer in a little special bone and I dreamed of snail shells and proving that harmonies formed interesting geometric patterns on the darned thing, and how maybe people who seemed chronically tuneless might be shown to have malformed ear bones -- until I finally got to see images of them in a bio textbook and realized that my dreams had to be crushed, this blobby thing, whatever else you say, is not working geometrically.

So a science of how music works physiologically and psychologically, is able to explain why rock and later certain forms of ambient and trance "felt good" to folks -- it took them right back into the womb: the distortion on the guitars felt like the swishing amniotic fluid, the four-on-the-floor sounded like a heartbeat, the indecipherable high-pitched vocals sounded like Mama's voice peeking through the noise. But beyond that, it's our experience with twanging strings and air blowing through wind instruments and the like, which informs what sounds familiar to our grown ears. And the proof is how robotic and alien pure sine waves sound: this is a part of your organ of Corti complaining, "hey, when these hairs are tickled usually those ones also tickle -- but they're just standing flat, what the hell is going on."

Lots of everyday things tickle the organ of Corti in patterns that resemble a major chord, so that sounds familiar to it. When you play a minor chord you deprive it of stimulation to some of those hairs but stimulate the ones a little more outward, and the organ says "there's something off, this thing is lower than I'd expect" and it's some sociology that you can do to say "when people are hurt they can communicate this most effectively to other pack animals through lower more mournful cries" and so there are semi-biological semi-cultural expectations that govern "lower = sadder" especially at low tempos. But you can do the same in reverse, play a sus4 chord, and it sounds weirdly brighter and you feedback through those semi-biological expectations in reverse, weird but with more energy than expected. But you can also just play minor scales uptempo and then they also change, the minor scale at a higher tempo has somehow more energy and less sadness than the major scale -- indeed rock music is full of minor pentatonic licks that nobody would ever describe as sad or painful or discomforting.