Supermassive black holes are generally at the center of galaxies, like a tiny yolk in an egg. That's not a hard rule. For instance, they can theoretically be ejected and make a mess if a few galaxies collide. But yes, it's harder to detect far away objects when the bulk of our milky way is in the way, making things milky. I suspect there are a lot of black holes back there that we just can't see.

On the other hand, the ancients assumed there had to be big continents in the southern and western hemispheres to "balance" the land in their own quadrant.

They turned out to be right, but not quite for the reasons they put forth.

As a non-cosmologist, I'm unwilling to speculate on what "should" be out there, because my mental model is probably very wrong (keeping in mind that our best models of what's happening out there are also probably quite wrong).