Anecdotally, I've found yearly physicals with full blood workup very helpful in heading off issues before they become much larger issues. For example, a random blood marker pointed at mold exposure. I thought that was strange, I didn't think we had any mold. Then I tore open one of my ceilings, there was a very slow leak in the bathroom above the top of that drywall was covered in mold. I replaced all of that drywall, and that blood marker shot down, and a few others improved drastically, and my energy levels improved. By going regularly, you get to see the trend lines on various things - those other markers had been going in a worrying direction over time.

I wonder how accurate that is. As in, these screenings are meant to detect early signs of issues like diabetes, liver problems, cholesterol, blood pressure, and so on. Is the case that many people are healthy and don't need it? That we haven't had a long enough sample time to know how screening in the 30s affects outcomes in the 60s?