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by toomuchtodo17 hours ago |
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upvoteby adjejmxbdjdn16 hours ago|
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First of all it’s a nice study. The dosages they always give are way too high and mice are rarely a reliable model.

But you’re also ignoring the fact that the same study shows that glucose inhibits the behavior.

So your claim that the study indicates its sugar is incorrect. The study indicates a possible impact from fructose which is countered by glucose, so the real issue is the fructose to glucose ratio.

Table sugar providing equal fructose and glucose molecules is acquitted by this study.

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upvoteby diath16 hours ago|
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> Western disease and sugar heavy diets broadly speaking

No, just being sedentary. There's no such thing as acquired diabetes in physically active people.

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upvoteby AlexErrant16 hours ago|
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To "actshully" you (because there are no absolutes in biology) pro-triathlete Lionel Sanders got his hba1c up to prediabetic range (5.9)

https://www.tri247.com/triathlon-news/elite/lionel-sanders-t...

Also age plays a pretty significant role. I know older asians who regularly walk who still got T2D. You could argue that walking isn't physically active enough... but they'd argue otherwise. It's all relative.

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upvoteby victorbjorklund16 hours ago|
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Doubt you can eat just pure fructose for 30 years and ”move” and avoid diabetes.
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upvoteby zemvpferreira16 hours ago|
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At the risk of being argumentative I had a horrible diet for the past ~10 years and carried 50 extra pounds. However I also exercised a lot as a hobby and to my shock my glucose and other bloods always came out in the normal range.

This year I started Mounjaro and dropped the 50 pounds. Curious to see what my next checkup shows.

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upvoteby victorbjorklund2 hours ago|
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I had horrible diet and no excersise for many years. Still skinny. One person says nothing about the whole pop.
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upvoteby AlexErrant16 hours ago|
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People kick around the idea of the "personal fat threshold". E.g. caucasians seem to be better at carrying fat than, say, Southeast Asians. White people seem to be able to better store fat without metabolic side effects; SEA seems to get T2D at a much lower bodyfat percentage.
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upvoteby zemvpferreira14 hours ago|
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Possibly maybe, but plenty of caucasian friends at my old bodyweight/fat percentage had/have horrible markers. I lean more towards the protective effect of exercise.
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upvoteby AlexErrant13 hours ago|
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Agree 100%. To quote myself:

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Which do you think is worse: smoking, or not exercising?

https://jamanetwork.com/journals/jamanetworkopen/fullarticle...

Look at Figure 2C in particular. The hazard ratio of smoking is 1.41. The hazard ratio between "Low" (<25th percentile) and "Below Average" (25th-49th percentile) cardiovascular health is 1.95.

In other words, it is better to be a smoker than in the lower 25% of non-exercisers. By far. It's not even close.

https://news.ycombinator.com/item?id=40080849

Let me emphasize: that exercise hazard ratio is between LOW and BELOW-AVERAGE.

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upvoteby gloryjulio16 hours ago|
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Sugar heavy diets is everywhere IF people can afford to have them if you look at the data. There is no such thing as Western vs Eastern in this sense.

Note I am not Western

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upvoteby Alien1Being16 hours ago|
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[flagged]
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upvoteby tptacek16 hours ago|
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I don't see anything RFK-like in that comment.
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upvoteby toomuchtodo16 hours ago|
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Just pattern matching as an autistic human. Similar results were seen on a ketogenic diet (and to some extent, intermittent fasting). What do they have in common? Sugar intake reduction. Is it surprising sugar potentially fuels cancer, contributes to dementia, etc? It shouldn’t be. It’s indirect and a casual connection.

There is no health benefit to a high sugar or Western diet, only downside. I think calling it poison is hyperbole, but it’s definitely not healthy, based on all available evidence. I expect to see longitudinal scale results over the next decade as everyone starts taking GLP-1s.

(I take a glp-1, they’re an amazing drug class, it changes how your brain operates, charlie day waving arms in front of a whiteboard meme here)

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upvoteby BenzeneDream16 hours ago|
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Thats due to caloric restriction. A high fat diet isn't going to helpful as well. To think that people cut sugar but continue to eat far too much meat and fat... yikes.
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