Not saying Sugar itself is much better, however, yes, there is research indicating that the two are metabolized differently, so that difference in composition should be considered.
They carry the same health risks if eaten in the same amounts. The only thing that corn syrup could be blamed for here is being too cheap so it shows up in greater quantity and in more products than cane sugar might otherwise.
HFCS is just one of those fashionable things to be "concerned" about so we can all miss the forest through the trees.
Seriously though, it's a dogshit thing to consume whether it is sweetened with HFCS or sucrose.
"Even today, a Soda with 'real sugar', at least for me, is far more satiating"
Did you know that in the acidic environment of a cola, sucrose quickly degrades into fructose and glucose (and if it didn't, your enzymes literally immediately crack sucrose into them). You know, exactly the same fructose and glucose that would be added by HFCS. The proportions differ a tiny amount, but this notion that one is satiating and the other isn't should really send you down a path of self-discovery, where you determine how you fell for nonsense.