But that's not too hard to work around. You can either have a single process that owns both writing and reading that file, or you can do a data lake where you post updates as parquet files into object storage, and duckdb handles the catalog. The Quack protocol also basically fixes this (though still in beta).
With Clickhouse, you can of course still have tenant separation, but you have to do it by managing users within Clickhouse that map to users/tenants of your main app, so that you can restrict SQL access by tenant to only their data store. Not a huge deal but I just like the Unix "it's just a file" simplicity of "Tenant A gets to run arbitrary SQL against their separate read-only, no-ATTACH duckdb file".
For our community DuckDB is the default data warehouse for local development environment. Last month +90,000 users used dlt (and their AI code editor) to load data into DuckDB.
Because of our proximity to the DuckDB community we are seeing enterprise DuckDB usage first hand. People imo sleep on the data volumes DuckDB can handle. We see Fortune 100 companies use dlt and DuckDB in production on their Lakehouses in hybrid cloud deployments. I can eg mention Stellantis (Chrysler, Jeep, Peugeot etc) because they talk about it publicly.
Clickhouse, as I mentioned, can be a good final layer, as can postgres.
You can still use duckdb for intermediate transformations, even if the final data lives elsewhere.
duckdb can also access various external sources, such as s3, so you could use duckdb for transformations and write "classic" parquet files to S3 and query them with an engine of your choice (which, again, could also be duckdb, but nothing stopping you from using Trino or something along those lines).
All a question of scale, complexity, cost, and latency. For reasonably low latency, shipping a duckdb file to the edge is fine, I think. Makes CI/deployments more complicated. Or you could assemble the actual duckdb file on site - probably easier with K8s and an init container that can scale? Something like that, I don't use K8s for SkaldMaps, but I have experimented a bit.
For SkaldMaps, the backend is written in go and has an abstraction to plug in a different presentation data store, so I would just need to re-wire data platform to write the final tables to e.g. CH instead of duckdb.
i put duckdb on a lambda and pointed it at s3 for the data. my data was closer to 2GB but the queries were quick and nearly free with superset pointed at it
is your setup running into problems that makes you need something more?