What if they're able to find hardware exploits and commandeer nearby access points across an air gap? What if they hack my brain waves to indoctrinate me? Etc
You still have to start with the basics regardless of speculative unknowns.
Treat models as untrusted and potentially compromised/hostile and proceed accordingly.
And hacking humans is the easiest part, we're a pretty greedy and power seeking bunch. We'll gladly let loose a digital demon if it promises us a trillon dollars.