I use the Master MX 3s specifically because of the "gestures" button, it was mandatory for me to replace using the trackpad. It's basically a thumb button you can press and combine with a mouse gesture to do the same thing as finger gestures on the trackpad. I mainly use the gestures left/right (to switch between full screen apps/main dektop) and up (mission control) but it's all configurable. It also has an horizontal scroll wheel that's very useful when using Excel or DB viewers.

I much prefer a mouse (I use the MX Vertical) to a trackpad for long periods of time at my desk.

Cmd+Scroll for zoom in/out, Ctrl+Left/Right arrows to switch spaces. It's not a fun as the trackpad, but those are things i don't do that often.