They seem to manage this just fine, but it's a pretty similar scenario. You could also push for standardized business costs and regulations eu wide ofc to help.
If you concentrated all manufacturing around just a few spots, you end up in a situation like India - inland states with resources get stripped of their resources while all the companies are based in coastal metropolises with port facilities.
One could also go the other way, like China, and let the states compete between themselves for manufacturing prowess, but you need a central planning committee to ensure that the competing provinces still coordinate and work to complement each other. Easier in China, not so much in the EU.
The EU single market is a sorry joke.