If you just want to run Qwen 3.8 27B and Deepseek v4 Flash in perpetuity and that's it, there are a lot of solutions that will work and this is a fairly user friendly one.
Lastly, I want to clarify that prefill on an x86 CPU is drastically slower than on an M5 Ultra GPU.
It feels like PCIe is a bit of a boat anchor here. There's a SATA->NVMe style transition waiting in the wings to make this all so much better. We really need post-PCIe GPUs. CXL with it's very small low latency flits. This is an "almost certainly not" but I wonder if you could mix PCIe and CXL so you could have the GPU memory expose vmeme as a bunch of CXL.mem pools but still have an otherwise pretty normal GPU. It seems madness that UALink went all in on GPU-to-GPU with no affordances for connecting to host computers.