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Good thing microorganisms are famous for their slow rate of change in dynamic environments…
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I'm not sure what this adds. The yeast here is chomping ethylene glycol for carbon, and tons of soil bacteria can already do that. And I should add that highly specialized industrial/lab yeasts have existed for a long time and aren't prevalent in the environment, they just don't like to grow outside of narrow(ish) conditions. Highly prevalent wild yeasts tend to eat a variety of sugars, not glycol.
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>Usually these bioengineered yeasts need pretty specific growth conditions in order to eat

Until, say, they mutate independently. Now, I have no idea how likely that is, but I think the fear is not baseless. There's a fun SF book, "Directive 51", which explores this a bit. Not a bad book to cuddle up with.

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Yeast drift a little but aren’t picking up new metabolic pathways very readily. Moreover these yeast don’t eat plastic they eat a component of PET in a bioreactor.
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Of course, the lysine contingency.
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> bioengineered yeasts need pretty specific growth conditions

In a natural environment this will not hold. Organisms are unstable; they change all the time, simpler ones even more so. Mutants with a faster growth rate will, up to a certain maximum, take over from slower growing or growth-deficient mutants. There isn't really a compelling growth advantage for plastic-degrading organisms, which is one reason why plastic stays so long in the environment.

All pre-processing steps further add to the cost, so we will year after year hear about it - and then wonder why nothing happens and plastics keep compounding in the ocean. And this is not new either: https://en.wikipedia.org/wiki/Diamond_v._Chakrabarty

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>In a natural environment this will not hold. Organisms are unstable; they change all the time, simpler ones even more so.

Jurassic narratives notwithstanding, unsure if this is a real problem. If you have a yeast that will only survive under narrow unnatural circumstances, I would expect freeing it into the wild with natural circumstances means it dies - not uses nature to find a way to destroy the world as a form of poetic justice for ever having been created.

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People who have never worked with anything biology related love to spout off about Jurassic Park. As a brewer I can assure you all that fancy special purpose yeasts just don’t turn into other stuff readily and often lose their modifications when they interact with wild yeasts.
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Are you perhaps misreading what I wrote, or am I misreading what you wrote? My reading of what you wrote makes me think you are interpreting me as claiming special purpose yeasts turn into other stuff readily, etc. etc.

on edit: my confusion stems from being the first to reference anything Jurassic in the conversation, so you sound somewhat accusatory.

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I was agreeing with you and tossing in my own 2¢.
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