These are all possible using light containers. For example, on FreeBSD I will spin up a jail which runs wireguard, and then I'll bridge that to another a jail. That 2nd jail is running entirely off wireguard without any other way to access the network. Since it is a jail, it is isolated. And backing up is as simple as a zfs snapshot and zfs send. I assume the same is possible on Linux.
There is an Issue for that: https://github.com/QubesOS/qubes-issues/issues/7051