That was a fiendish thing to debug; if I recall correctly it was a slightly and intermittently defective connector.
replyI’m fine with that. Put it at the feet of pop science blogging.
replyI’m less fine with the time and resources spent on mouse models. They already know you’d get the same utility from a magic 8 ball, but they do it anyway.
Mouse models are useful to discard very bad ideas. There was a recent experiment to use bacteria to kill cancer https://news.ycombinator.com/item?id=46306894 They tried like 40 bacterias in vitro, then like 9 in mice, and only 1 was useful in mice and they will continue only with that, perhaps in humans. Anyway, as you suggest, there is a high chance it will fail.
replyAlso, you can do nasty stuff to mice that would never be allowed with humans. In that experiment they injected cancer cells in mice with a bad inmune system, so they could get like 90 mice with cancer and run the experiment in a short time. No ethical committee would approve that in humans.