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GLPs have lower effectiveness for the vast majority of overweight and fat people than macrocodex. You can look up GLP non-responder data; furthermore, many people use GLP-1 in a knee-jerk fashion, crashing their nutrition, which may result in loss of lean mass, bile issues, and gallbladder stone risks.

And i am not the only one who is saying this, look at this: https://www.reddit.com/r/tirzepatidecompound/comments/1omfgx...

If GLP-1 are effective, then why do people who are using GLP-1 for some time need this guide (macrocodex's guide)?

Macrocodex has 16,000+ users and it's free, there are no ads so there is nothing to sell there.

Here you can see our GLP dosing protocol: https://macrocodex.app/knowledge/rethink/glp-1-agonists-dosi...

Our group has 2000+ people and macrocodex users beat GLP1 drug users by long shot.

You can find even more evidence by searching for "macrocodex" reviews. Very simple and doesn't cost anything

by lloydarmbrust2 hours ago|

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I'm just asking if you've ever used one.

I don't want to assume, but if you've used one, you would understand the benefits are far greater than weight loss.

by bertylicious1 hours ago|

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What exactly are these benefits beyond weight loss?

by faangguyindia2 hours ago|

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Exercise, diet, being active, and having slightly above average lean mass and staying below 15% body fat as a male and below 24% for a female have a far bigger benefit than just shooting GLP drugs.

I don't need GLPs, but I've experimented with it for a short while, and I don't see any benefit other than appetite reduction, which I do not need as I have an active life.

by tomhow31 minutes ago|

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Please don't harangue people about exercise and diet on HN. Everyone has heard it countless times here and elsewhere. Obviously, many people find that approach doesn't (easily) work. Yes, it's well known GLP-1s can have negative effects. Many people still find them beneficial anyway, and many people take measures to address the negative effects. None of this is simple or easy, so please stop making it out like it should be a simple or easy decision for people to just do as you suggest.

In HN guidelines terms, these sections are relevant:

Be kind. Don't be snarky. Converse curiously; don't cross-examine. Edit out swipes.

Comments should get more thoughtful and substantive, not less, as a topic gets more divisive.

Eschew flamebait. Avoid generic tangents. Omit internet tropes.

Please don't post shallow dismissals, especially of other people's work. A good critical comment teaches us something.

https://news.ycombinator.com/newsguidelines.html