Extreme configurations with high difficulty do make for a frustrating experience on very old devices, but in practice it rarely gets in the way.
Only the tail end of what one could consider normal users (those running custom browsers or having JS disabled or nonfunctional) run into issues here, but they'll have these issues with any other bot-blocking mechanism that still offers some protection these days.
Apple's "ask your vendor for tokens to exchange for access" web standard gets around this, assuming those bespoke and Javascript-less browsers implement PATs, but that standard seems to be completely dead in the water outside of Safari.
That's entirely up to how the site operator configures the PoW challenge.
> anyone with even a moderate amount of funding in the AI space, who aren't even slightly slowed down
Do you have any evidence that it is the large well funded AI companies DoSing sites by (for example) scraping absurd numbers of permutations of cgit url parameters?
Even if it is (which I doubt), if all this accomplishes is getting them to spend 10 minutes optimizing their bots to not do that it will be a major win.